Stem Cell

Existing Drug Found to be Effective at Killing Cancer Stem Cells

Existing Drug Found to be Effective at Killing Cancer Stem Cells
Researchers experiment with the Sam68 protein. Credit: McMaster University

A team of researchers at McMaster University has identified a unique feature of cancer stem cells that can be exploited to kill the deadly cells thought to be the reason that cancer comes back after therapy. Understanding this feature will be useful for delivering more targeted cancer therapeutics to the right patients.

The study, published today in the scientific journal Cell Chemical Biology, reveals that an existing set of drugs is effective in killing cancer stem cells and explains how this led the team to uncovering important details about how these cells are working in human tumors.

“The drugs helped us to understand the biology,” said Mick Bhatia, principal investigator of the study and scientific director of the McMaster Stem Cell and Cancer Research Institute. “We’ve worked backwards, employing a series of drugs used in the clinic to understand a new way that cancer stem cells…