Stem Cell

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma

Identification of PTPRZ as a drug target for cancer stem cells in glioblastoma
The left and right show xenograft tumors of parental cells and PTPRZ knockdown cells, respectively. Credit: NIBB

Glioblastoma is a malignant brain tumor with high mortality. Cancer stem cells are thought to be crucial for tumor initiation and its recurrence after standard therapy with radiation and temozolomide (TMZ) chemotherapy. Protein tyrosine phosphatase receptor type Z (PTPRZ) is an enzyme that is highly expressed in glioblastoma, especially in cancer stem cells.

The research group of Professor Masaharu Noda and Researcher Akihiro Fujikawa of the National Institute for Basic Biology (NIBB) showed that the enzymatic activity of PTPRZ is…